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Silicon microprobes

We have developed silicon microprobes containing up to 256 electrodes optimized for recording large-scale neural activity (single-unit and LFP). Thanks to support from the NSF NeuroNex program we have previously offered large quantities of microprobes as open-source, low-cost tools to the neuroscience community. In total we have shared nearly 2,000 probes with dozens of labs around the world. We are no longer actively engaged in disseminating these tools, but continue to heavily rely on silicon probes in our own neuroscience research. The technology can be combined with optical fibers to enable electrophysiology alongside optogenetics or photometry. Further information on their design and use is provided below:

Click here to download information on previously available microprobe designs, packaging, compatible hardware options, and miscellaneous information on using the probes (e.g., electroplating, epoxy encapsulation, wirebond pad dimensions).

Also visit our Github file repository for information on electrode maps, design files, instructional videos, and other resources.

Here is a paper on technical aspects related to the silicon microprobes.

Here is a preprint illustrating how our silicon microprobes can be combined with fiber photometry to study dopaminergic modulation of striatal dynamics.

Here is a paper illustrating how our silicon microprobes can be combined with optogenetics to study striatal interneuron function.